Natural and bioinspired excipients for dry powder inhalation formulations
Daan Zillen¹, Max Beugeling¹, Wouter L. J. Hinrichs, Henderik W. Frijlink and Floris Grasmeijer ¹These authors contributed equally to this work Pulmonary drug delivery can have several advantages over other administration routes, in particular when using dry powder formulations. Such dry powder inhalation formulations generally include natural and bio-inspired excipients, which, among other purposes, are used to improve dosing reproducibility and aerosolization performance. Amino acids can enhance powder dispersibility and provide protection against moisture uptake....